West, KL;
Kelm, ND;
Carson, RP;
Alexander, DC;
Gochberg, DF;
Does, MD;
(2017)
Experimental studies of g-ratio MRI in ex vivo mouse brain.
NeuroImage
, 167
pp. 366-371.
10.1016/j.neuroimage.2017.11.064.
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Abstract
This study aimed to experimentally evaluate a previously proposed MRI method for mapping axonal g-ratio (ratio of axon diameters, measured to the inner and outer boundary of myelin). MRI and electron microscopy were used to study excised and fixed brains of control mice and three mouse models of abnormal white matter. The results showed that g-ratio measured with MRI correlated with histological measures of myelinated axon g-ratio, but with a bias that is likely due to the presence of non-myelinated axons. The results also pointed to cases where the MRI g-ratio model simplifies to be primarily a function of total myelin content.
| Type: | Article |
|---|---|
| Title: | Experimental studies of g-ratio MRI in ex vivo mouse brain |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuroimage.2017.11.064 |
| Publisher version: | http://dx.doi.org/10.1016/j.neuroimage.2017.11.064 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Diffusion, G-ratio, MRI, Microstructure, Myelin, Relaxometry |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10044619 |
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