Nakata, K;
Ito, Y;
Magadi, W;
Bonaventure, A;
Stiller, CA;
Katanoda, K;
Matsuda, T;
... Rachet, B; + view all
(2017)
Childhood cancer incidence and survival in Japan and England: A population-based study (1993-2010).
Cancer Science
, 109
(2)
pp. 422-434.
10.1111/cas.13457.
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Abstract
The present study aimed to compare cancer incidence and trends in survival for children diagnosed in Japan and England, using population-based cancer registry data. The analysis was based on 5192 children with cancer (age 0-14 years) from 6 prefectural cancer registries in Japan and 21 295 children diagnosed in England during 1993-2010. Differences in incidence rates between the 2 countries were measured with Poisson regression models. Overall survival was estimated using the Kaplan–Meier method. Incidence rates for Hodgkin lymphoma, renal tumors and Ewing sarcomas in England were more than twice as high as those in Japan. Incidence of germ cell tumors, hepatic tumors, neuroblastoma and acute myeloid leukemia (AML) was higher in Japan than in England. Incidence of all cancers combined decreased in Japan throughout the period 1993 to 2010, which was mainly explained by a decrease in registration of neuroblastoma in infants. For many cancers, 5-year survival improved in both countries. The improvement in survival in chronic myeloid leukemia (CML) was particularly dramatic in both countries. However, 5-year survival remained less than 80% in 2005-2008 in both countries for AML, brain tumors, soft tissue sarcomas, malignant bone tumors and neuroblastoma (age 1-14 years). There were significant differences in incidence of several cancers between countries, suggesting variation in genetic susceptibility and possibly environmental factors. The decrease in incidence for all cancers combined in Japan was related to the cessation of the national screening program for neuroblastoma. The large improvement in survival in CML coincided with the introduction of effective therapy (imatinib).
| Type: | Article |
|---|---|
| Title: | Childhood cancer incidence and survival in Japan and England: A population-based study (1993-2010) |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/cas.13457 |
| Publisher version: | https://doi.org/10.1111/cas.13457 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Oncology, cancer registry data, childhood cancer, childhood cancer incidence and survival, epidemiology, population-based study, CHRONIC MYELOID-LEUKEMIA, ADOLESCENT CANCER, INDIVIDUAL DATA, GREAT-BRITAIN, WILMS-TUMORS, CHILDREN, TRENDS, AGE, NEUROBLASTOMA, REGISTRIES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10044587 |
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