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Hierarchically designed hybrid nanoparticles for combinational photochemotherapy against a pancreatic cancer cell line

Joubert, F; Pasparakis, G; (2018) Hierarchically designed hybrid nanoparticles for combinational photochemotherapy against a pancreatic cancer cell line. Journal of Materials Chemistry B , 6 (7) pp. 1095-1104. 10.1039/c7tb03261g. Green open access

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Abstract

© The Royal Society of Chemistry 2018. Here, we report the formulation of hybrid nanoparticles consisting of aggregated gold nanoparticles (GNPs) impregnated into a gemcitabine-polymer conjugate matrix that exhibit synergistic photo-chemo-therapeutic activity against pancreatic cancer. Well-defined, sub-100 nm hybrid NPs were successfully formulated and their photothermal conversion efficiency was evaluated, which was found to be as high as 63% in the red-visible spectrum. By varying the GNP and GEM-polymer feed, it was possible to control the red-shifting of the surface plasmon resonance at therapeutically relevant wavelengths. The hybrid NPs exhibited significant cytotoxicity against MiaPaCa-2 cells with a half-maximal inhibitory concentration (IC 50 ) of 0.0012 mg mL -1 ; however the IC 50 decreased by a factor of 2 after the cells were irradiated with a continuous wave red laser for 1 min (1.4 W cm -2 ). Although the irradiation of the aggregated GNPs loaded in the hybrid NPs produced a higher thermal effect for the same amount of non-loaded GNPs, the IC 50 of the hybrid NPs was significantly lower than that of the free GNPs, hence indicating a synergistic effect of the polymer bound GEM and the GNPs.

Type: Article
Title: Hierarchically designed hybrid nanoparticles for combinational photochemotherapy against a pancreatic cancer cell line
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c7tb03261g
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10044412
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