UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Coupling of Rigor Mortis and Intestinal Necrosis During C. elegans Organismal Death

Galimov, E; Pryor, R; POOLE, S; Benedetto, A; Pincus, Z; Gems, D; (2018) Coupling of Rigor Mortis and Intestinal Necrosis During C. elegans Organismal Death. Cell Reports , 22 (10) pp. 2730-2741. 10.1016/j.celrep.2018.02.050. Green open access

[thumbnail of Published article]
Preview
Text (Published article)
Galimov_1-s2.0-S2211124718302316-main.pdf - Published Version

Download (4MB) | Preview
[thumbnail of Supplementary file 1]
Preview
Text (Supplementary file 1)
1-s2.0-S2211124718302316-mmc1.pdf

Download (6MB) | Preview
[thumbnail of Supplementary file 2] Spreadsheet (Supplementary file 2)
1-s2.0-S2211124718302316-mmc2.xlsx

Download (101kB)
[thumbnail of Supplementary file 3] Video (Supplementary file 3)
1-s2.0-S2211124718302316-mmc3.mp4

Download (11MB)
[thumbnail of Supplementary file 4] Video (Supplementary file 4)
1-s2.0-S2211124718302316-mmc4.mp4

Download (1MB)
[thumbnail of Supplementary file 5] Video (Supplementary file 5)
1-s2.0-S2211124718302316-mmc5.mp4

Download (8MB)
[thumbnail of Supplementary file 6] Video (Supplementary file 6)
1-s2.0-S2211124718302316-mmc6.mp4

Download (6MB)
[thumbnail of Supplementary file 7] Video (Supplementary file 7)
1-s2.0-S2211124718302316-mmc7.mp4

Download (2MB)
[thumbnail of Supplementary file 8] Archive (Supplementary file 8)
1-s2.0-S2211124718302316-mmc8.zip

Download (5kB)

Abstract

Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe another feature of organismal death, a wave of body wall muscle contraction, or death contraction (DC). This phenomenon is accompanied by a wave of intramuscular Ca2+ release and, subsequently, of intestinal necrosis. Correlation of directions of the DC and intestinal necrosis waves implies coupling of these death processes. Long-lived insulin/IGF-1-signaling mutants show reduced DC and delayed intestinal necrosis, suggesting possible resistance to organismal death. DC resembles mammalian rigor mortis, a postmortem necrosis-related process in which Ca2+ influx promotes muscle hyper-contraction. In contrast to mammals, DC is an early rather than a late event in C. elegans organismal death.

Type: Article
Title: Coupling of Rigor Mortis and Intestinal Necrosis During C. elegans Organismal Death
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.celrep.2018.02.050
Publisher version: https://doi.org/10.1016/j.celrep.2018.02.050
Language: English
Additional information: Copyright © 2018 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: aging, ATP, calcium, C. elegans, muscle, necrosis, organismal death, pathology, rigor mortis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10044243
Downloads since deposit
40Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item