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HIC2 regulates isoform switching during maturation of the cardiovascular system

Dykes, IM; van Bueren, KL; Scambler, PJ; (2018) HIC2 regulates isoform switching during maturation of the cardiovascular system. Journal of Molecular and Cellular Cardiology , 114 pp. 29-37. 10.1016/j.yjmcc.2017.10.007. Green open access

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Abstract

Physiological changes during embryonic development are associated with changes in the isoform expression of both myocyte sarcomeric proteins and of erythrocyte haemoglobins. Cell type-specific isoform expression of these genes also occurs. Although these changes appear to be coordinated, it is unclear how changes in these disparate cell types may be linked. The transcription factor Hic2 is required for normal cardiac development and the mutant is embryonic lethal. Hic2 embryos exhibit precocious expression of the definitive-lineage haemoglobin Hbb-bt in circulating primitive erythrocytes and of foetal isoforms of cardiomyocyte genes (creatine kinase, Ckm, and eukaryotic elongation factor Eef1a2) as well as ectopic cardiac expression of fast-twitch skeletal muscle troponin isoforms. We propose that HIC2 regulates a switching event within both the contractile machinery of cardiomyocytes and the oxygen carrying systems during the developmental period where demands on cardiac loading change rapidly.

Type: Article
Title: HIC2 regulates isoform switching during maturation of the cardiovascular system
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.yjmcc.2017.10.007
Publisher version: https://doi.org/10.1016/j.yjmcc.2017.10.007
Language: English
Additional information: Copyright © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
Keywords: Congenital heart disease, Creatine kinase, Embryonic development, Haemoglobin, Myoglobin, Troponin
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10044209
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