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Multiple sclerosis risk perception and acceptance for Brazilian patients

Bichuetti, DB; Franco, CA; Elias, I; Mendonca, ACR; Diniz Carvalho, LF; Diniz, DS; Tur, C; ... Lobato de Oliveira, EM; + view all (2018) Multiple sclerosis risk perception and acceptance for Brazilian patients. Arquivos de Neuro-Psiquiatria , 76 (1) pp. 6-12. 10.1590/0004-282X20170167. Green open access

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Abstract

The perception of multiple sclerosis (MS) severity and risk associated with therapies might influence shared decision making in different countries. We investigated the perception of MS severity and factors associated with risk acceptance in Brazil in 96 patients with relapsingremitting MS using a standardized questionnaire and compared this with two European cohorts. Multiple sclerosis was perceived as a very severe disease and the risk of developing progressive multifocal leukoencephalopathy due to natalizumab was seen as moderate to high. Seventy-six percent considered a risk of 1:1,000, or higher, an impediment for natalizumab use. Older age was the only variable associated with higher risk acceptance and our patients showed a more conservative profile than German and Spanish patients. Our patients perceived MS severity and progressive multifocal leukoencephalopathy risk similarly to elsewhere, but their willingness to take risks was more conservative. This should be considered when discussing therapeutic options and it might have an impact on guideline adaptations.

Type: Article
Title: Multiple sclerosis risk perception and acceptance for Brazilian patients
Open access status: An open access version is available from UCL Discovery
DOI: 10.1590/0004-282X20170167
Publisher version: http://doi.org/10.1590/0004-282X20170167
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: multiple sclerosis; natalizumab; risk-taking; risk assessment, decision making.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10043979
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