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Building membrane nanopores

Howorka, S; (2017) Building membrane nanopores. [Review]. Nature Nanotechnology , 12 (7) pp. 619-630. 10.1038/NNANO.2017.99. Green open access

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Membrane nanopores—hollow nanoscale barrels that puncture biological or synthetic membranes—have become powerful tools in chemical- and biosensing, and have achieved notable success in portable DNA sequencing. The pores can be self-assembled from a variety of materials, including proteins, peptides, synthetic organic compounds and, more recently, DNA. But which building material is best for which application, and what is the relationship between pore structure and function? In this Review, I critically compare the characteristics of the different building materials, and explore the influence of the building material on pore structure, dynamics and function. I also discuss the future challenges of developing nanopore technology, and consider what the next-generation of nanopore structures could be and where further practical applications might emerge.

Type: Article
Title: Building membrane nanopores
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/NNANO.2017.99
Publisher version: http://doi.org/10.1038/NNANO.2017.99
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Bionanoelectronics, Nanopores
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10043880
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