Pezic, D;
Weeks, SL;
Hadjur, S;
(2017)
More to cohesin than meets the eye: complex diversity for fine-tuning of function.
Current Opinion in Genetics & Development
, 43
pp. 93-100.
10.1016/j.gde.2017.01.004.
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Abstract
Recent years have witnessed a dramatic expansion in our understanding of gene control. It is now widely appreciated that the spatial organization of the genome and the manner in which genes and regulatory elements are embedded therein has a critical role in facilitating the regulation of gene expression. The loop structures that underlie chromosome organization are anchored by cohesin complexes. Several components of the cohesin complex have multiple paralogs, leading to different levels of cohesin complex variants in cells. Here we review the current literature around cohesin variants and their known functions. We further discuss how variation in cohesin complex composition can result in functional differences that can impact genome organization and determine cell fate.
| Type: | Article |
|---|---|
| Title: | More to cohesin than meets the eye: complex diversity for fine-tuning of function |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.gde.2017.01.004 |
| Publisher version: | https://doi.org/10.1016/j.gde.2017.01.004 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10043742 |
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