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Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1

Effertz, T; Nadrowski, B; Piepenbrock, D; Albert, JT; Goepfert, MC; (2012) Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1. Nature Neuroscience , 15 (9) pp. 1198-1200. 10.1038/nn.3175. Green open access

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Abstract

The elusive transduction channels for hearing are directly gated mechanically by the pull of gating springs. We found that the transient receptor potential (TRP) channel TRPN1 (NOMPC) is essential for this direct gating of Drosophila auditory transduction channels and that the channel-spring complex was disrupted if TRPN1 was lost. Our results identify TRPN1 as a mechanical constituent of the fly's auditory transduction complex that may act as the channel and/or gating spring.

Type: Article
Title: Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nn.3175
Publisher version: http://dx.doi.org/10.1038/nn.3175
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, HAIR CELL, CHANNEL, NOMPC, MECHANOTRANSDUCTION, HEARING, SOUND, EAR
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10043564
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