Hernandez-Fuentes, MP;
Franklin, C;
Rebollo-Mesa, I;
Mollon, J;
Delaney, F;
Perucha, E;
Stapleton, C;
... United Kingdom and Ireland Renal Transplant Consortium (UKIRTC); + view all
(2018)
Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study.
American Journal of Transplantation
, 18
(6)
pp. 1370-1379.
10.1111/ajt.14594.
Preview |
Text
Powis VoR Hernandez-Fuentes_et_al-2018-American_Journal_of_Transplantation.pdf - Published Version Download (938kB) | Preview |
Abstract
Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combining patient data and samples from supranational cohorts across the United Kingdom and European Union, we performed the first large-scale genome-wide association study analyzing both donor and recipient DNA in 2094 complete renal transplant-pairs with replication in 5866 complete pairs. We studied deceased-donor grafts allocated on the basis of preferential HLA matching, which provided some control for HLA genetic effects. No strong donor or recipient genetic effects contributing to long- or short-term allograft survival were found outside the HLA region. We discuss the implications for future research and clinical application.
| Type: | Article |
|---|---|
| Title: | Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/ajt.14594 |
| Publisher version: | http://dx.doi.org/10.1111/ajt.14594 |
| Language: | English |
| Additional information: | © 2018 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Basic (laboratory) research/science, genomics, graft survival, kidney transplantation/nephrology, rejection, translational research/science |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10043562 |
Archive Staff Only
 |
View Item |
