Vasiliadou, R;
Welham, KJ;
(2017)
Simulating the phase II metabolism of raloxifene on a screen-printed electrode.
Canadian Journal of Chemistry
, 95
(10)
pp. 1085-1089.
10.1139/cjc-2017-0279.
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Abstract
Raloxifene (RLX) is a selective estrogen receptor modulator widely used for the treatment of osteoporosis in post-menopause women. Toxicological in vitro studies suggested the reactivity of RLX through phase I metabolism. Herein, we describe a simple and inexpensive method for monitoring the reactive metabolism and detoxification of RLX by electrochemistry (EC) and mass spectrometry (MS). The phase I metabolite was synthesized electrochemically on a screen-printed electrode (SPE) and subsequently reacted with glutathione (GSH). The resulted GSH-adducts and GSH disulfides were characterized off-line by electrospray ionization (ESI)–MS.
| Type: | Article |
|---|---|
| Title: | Simulating the phase II metabolism of raloxifene on a screen-printed electrode |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1139/cjc-2017-0279 |
| Publisher version: | https://doi.org/10.1139/cjc-2017-0279 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, raloxifene, screen-printed electrodes, metabolism, toxicity, CARBON ELECTRODE, ELECTROCHEMISTRY, ACETAMINOPHEN, UPDATE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10043437 |
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