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Simulating the phase II metabolism of raloxifene on a screen-printed electrode

Vasiliadou, R; Welham, KJ; (2017) Simulating the phase II metabolism of raloxifene on a screen-printed electrode. Canadian Journal of Chemistry , 95 (10) pp. 1085-1089. 10.1139/cjc-2017-0279. Green open access

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Abstract

Raloxifene (RLX) is a selective estrogen receptor modulator widely used for the treatment of osteoporosis in post-menopause women. Toxicological in vitro studies suggested the reactivity of RLX through phase I metabolism. Herein, we describe a simple and inexpensive method for monitoring the reactive metabolism and detoxification of RLX by electrochemistry (EC) and mass spectrometry (MS). The phase I metabolite was synthesized electrochemically on a screen-printed electrode (SPE) and subsequently reacted with glutathione (GSH). The resulted GSH-adducts and GSH disulfides were characterized off-line by electrospray ionization (ESI)–MS.

Type: Article
Title: Simulating the phase II metabolism of raloxifene on a screen-printed electrode
Open access status: An open access version is available from UCL Discovery
DOI: 10.1139/cjc-2017-0279
Publisher version: https://doi.org/10.1139/cjc-2017-0279
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, raloxifene, screen-printed electrodes, metabolism, toxicity, CARBON ELECTRODE, ELECTROCHEMISTRY, ACETAMINOPHEN, UPDATE
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10043437
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