Peters, AJ;
Lee, J;
Hedrick, NG;
O'Neil, K;
Komiyama, T;
(2017)
Reorganization of corticospinal output during motor learning.
Nature Neuroscience
, 20
(8)
pp. 1133-1141.
10.1038/nn.4596.
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Abstract
Motor learning is accompanied by widespread changes within the motor cortex, but it is unknown whether these changes are ultimately funneled through a stable corticospinal output channel or whether the corticospinal output itself is plastic. We investigated the consistency of the relationship between corticospinal neuron activity and movement through in vivo two-photon calcium imaging in mice learning a lever-press task. Corticospinal neurons exhibited heterogeneous correlations with movement, with the majority of movement-modulated neurons decreasing activity during movement. Individual cells changed their activity across days, which led to changed associations between corticospinal activity and movement. Unlike previous observations in layer 2/3, activity accompanying learned movements did not become more consistent with learning; instead, the activity of dissimilar movements became more decorrelated. These results indicate that the relationship between corticospinal activity and movement is dynamic and that the types of activity and plasticity are different from and possibly complementary to those in layer 2/3.
Type: | Article |
---|---|
Title: | Reorganization of corticospinal output during motor learning |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1038/nn.4596 |
Publisher version: | https://doi.org/10.1038/nn.4596 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, NEURONS IN-VIVO, PYRAMIDAL TRACT, CORTICOSTRIATAL PLASTICITY, CORTEX, SKILL, RAT, CONNECTIONS, FORELIMB, MOVEMENT, MUSCLE |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
URI: | https://discovery.ucl.ac.uk/id/eprint/10043327 |
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