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Time-Domain Functional Diffuse Optical Tomography System Based on Fiber-Free Silicon Photomultipliers

Farina, A; Tagliabue, S; Di Sieno, L; Martinenghi, E; Durduran, T; Arridge, S; Martelli, F; ... Dalla Mora, A; + view all (2017) Time-Domain Functional Diffuse Optical Tomography System Based on Fiber-Free Silicon Photomultipliers. Applied Sciences , 7 (12) , Article 1235. 10.3390/app7121235. Green open access

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Abstract

Based on recent developments in both single-photon detectors and timing electronic circuits, we designed a compact and cost effective time-domain diffuse optical tomography system operated at 1 Hz acquisition rate, based on eight silicon photomultipliers and an 8-channel time-to-digital converter. The compact detectors are directly hosted on the probe in a circular arrangement around a single light injection fiber, so to maximize light harvesting. Tomography is achieved exploiting the depth sensitivity that is encoded in the arrival time of detected photons. The system performances were evaluated on simulations to assess possible the limitations arising from the use of a single injection point, and then on phantoms and in vivo to prove the eligibility of these technologies for diffuse optical tomography.

Type: Article
Title: Time-Domain Functional Diffuse Optical Tomography System Based on Fiber-Free Silicon Photomultipliers
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/app7121235
Publisher version: https://doi.org/10.3390/app7121235
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Physical Sciences, Technology, Chemistry, Multidisciplinary, Materials Science, Multidisciplinary, Physics, Applied, Chemistry, Materials Science, Physics, functional imaging, diffuse optical tomography, time-correlated single-photon counting, silicon photomultipliers, NEAR-INFRARED SPECTROSCOPY, PHOTON MIGRATION, BRAIN-FUNCTION, BREAST, CONTAMINATION, INSTRUMENTS, SENSITIVITY, GENERATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/10043326
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