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Physical activity pre- and post-dementia: English Longitudinal Study of Ageing

Soni, M; Orrell, M; Bandelow, S; Steptoe, A; Rafnsson, S; d'Orsi, E; Xavier, A; (2017) Physical activity pre- and post-dementia: English Longitudinal Study of Ageing. Aging & Mental Health 10.1080/13607863.2017.1390731. (In press). Green open access

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Abstract

BACKGROUND: To inform public health interventions, further investigation is needed to identify: (1) frequency/intensity of everyday physical activity (PA) needed to reduce dementia risk; (2) whether post-diagnosis reduction in PA is associated with cognitive outcomes in people with dementia. METHODS: Data from 11,391 men and women (aged ≥50) were obtained from the English Longitudinal Study of Ageing cohort. Assessments were carried out at baseline (2002-2003) and at biannual follow-ups (2004-2013). RESULTS: Older adults who carried out moderate to vigorous activity at least once per week had a 34%-50% lower risk for cognitive decline and dementia over an 8-10 year follow-up period. From pre- to post-dementia diagnosis, those who decreased PA levels had a larger decrease in immediate recall scores, compared to those who maintained or increased PA levels (analyses were adjusted for changes in physical function). CONCLUSION: PA was associated with cognitive outcomes in a dose-dependent manner. Reduction in PA after diagnosis was associated with accelerated cognitive decline and maintaining PA may reduce symptom progression in dementia.

Type: Article
Title: Physical activity pre- and post-dementia: English Longitudinal Study of Ageing
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/13607863.2017.1390731
Publisher version: http://doi.org/10.1080/13607863.2017.1390731
Language: English
Additional information: © 2017 Informa UK Limited, trading as Taylor & Francis Group. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer's disease, cognitive functioning, epidemiology (dementia), other dementias, physical activity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
URI: https://discovery.ucl.ac.uk/id/eprint/10043249
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