Kohler, S;
Voß, F;
Gómez Mejia, A;
Brown, JS;
Hammerschmidt, S;
(2016)
Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion.
FEBS Letters
, 590
(21)
pp. 3820-3839.
10.1002/1873-3468.12352.
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Abstract
Streptococcus pneumoniae (pneumococcus) has evolved sophisticated strategies to survive in several niches within the human body either as a harmless commensal or as a serious pathogen causing a variety of diseases. The dynamic interaction between pneumococci and resident host cells during colonization of the upper respiratory tract and at the site of infection is critical for bacterial survival and the development of disease. Pneumococcal lipoproteins are peripherally anchored membrane proteins and have pivotal roles in bacterial fitness including envelope stability, cell division, nutrient acquisition, signal transduction, transport (as substrate-binding proteins of ABC transporter systems), resistance to oxidative stress and antibiotics, and protein folding. In addition, lipoproteins are directly involved in virulence-associated processes such as adhesion, colonization, and persistence through immune evasion. Conversely, lipoproteins are also targets for the host response both as ligands for toll-like receptors and as targets for acquired antibodies. This review summarizes the multifaceted roles of selected pneumococcal lipoproteins and how this knowledge can be exploited to combat pneumococcal infections.
| Type: | Article |
|---|---|
| Title: | Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/1873-3468.12352 |
| Publisher version: | https://doi.org/10.1002/1873-3468.12352 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Streptococcus pneumoniae, antibacterial therapy, immune response, lipoprotein, virulence, Bacterial Adhesion, Bacterial Proteins, Drug Resistance, Bacterial, Host-Pathogen Interactions, Humans, Immune Evasion, Lipoproteins, Pneumococcal Infections, Streptococcus pneumoniae, Virulence |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10043060 |
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