Gronland, GR;
Ramos, A;
(2017)
The devil is in the domain: understanding protein recognition of multiple RNA targets.
Biochemical Society Transactions
, 45
(6)
pp. 1305-1311.
10.1042/BST20160362.
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Abstract
RNA regulation provides a finely tuned and highly co-ordinated control of gene expression. Regulation is mediated by hundreds to thousands of multi-functional RNA-binding proteins which often interact with large sets of RNAs. In this brief review, we focus on a recent work that highlights how the proteins use multiple RNA-binding domains to interact selectively with the different RNA targets. Deconvoluting the molecular complexity of the RNA regulatory network is essential to understanding cell differentiation and function, and requires accurate models for protein–RNA recognition and protein target selectivity. We discuss that the structural and molecular understanding of the key determinant of recognition, together with the availability of methods to examine protein–RNA interactions at the transcriptome level, may provide an avenue to establish these models.
| Type: | Article |
|---|---|
| Title: | The devil is in the domain: understanding protein recognition of multiple RNA targets |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1042/BST20160362 |
| Publisher version: | http://dx.doi.org/10.1042/BST20160362 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, PRE-MESSENGER-RNA, BINDING-PROTEIN, SPLICING REGULATION, POSTTRANSCRIPTIONAL CONTROL, STRUCTURAL BASIS, GENE-EXPRESSION, STEM-CELLS, KH DOMAINS, PAR-CLIP, TRANSLATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10042989 |
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