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In vivo 3-dimensional photoacoustic imaging of the renal vasculature in preclinical rodent models

Ogunlade, O; Connell, JJ; Huang, JL; Zhang, E; Lythgoe, MF; Long, DA; Beard, P; (2018) In vivo 3-dimensional photoacoustic imaging of the renal vasculature in preclinical rodent models. American Journal of Physiology - Renal Physiology , 314 (6) F1145-F1153. 10.1152/ajprenal.00337.2017. Green open access

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Abstract

In vivo three-dimensional photoacoustic imaging of the renal vasculature in preclinical rodent models. Am J Physiol Renal Physiol 314: F1145–F1153, 2018. First published December 20, 2017; doi:10.1152/ajprenal.00337.2017.—Noninvasive imaging of the kidney vasculature in preclinical murine models is important for the assessment of renal development, studying diseases and evaluating new therapies but is challenging to achieve using existing imaging modalities. Photoacoustic imaging is a promising new technique that is particularly well suited to visualizing the vasculature and could provide an alternative to existing preclinical imaging methods for studying renal vascular anatomy and function. To investigate this, an all-optical Fabry-Perot-based photoacoustic scanner was used to image the abdominal region of mice. High-resolution three-dimensional, noninvasive, label-free photoacoustic images of the mouse kidney and renal vasculature were acquired in vivo. The scanner was also used to visualize and quantify differences in the vascular architecture of the kidney in vivo due to polycystic kidney disease. This study suggests that photoacoustic imaging could be utilized as a novel preclinical imaging tool for studying the biology of renal disease.

Type: Article
Title: In vivo 3-dimensional photoacoustic imaging of the renal vasculature in preclinical rodent models
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1152/ajprenal.00337.2017
Publisher version: http://doi.org/10.1152/ajprenal.00337.2017
Language: English
Additional information: Copyright © 2018 the American Physiological Society. Licensed under Creative Commons Attribution CC-BY 4.0.
Keywords: photoacoustic imaging; renal vasculature; polycystic kidney disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10042961
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