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Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells

Trevers, KE; Prajapati, RS; Hintze, M; Stower, MJ; Strobl, AC; Tambalo, M; Ranganathan, R; ... Streit, A; + view all (2018) Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells. Proceedings of the National Academy of Sciences of the United States of America , 115 (2) pp. 355-360. 10.1073/pnas.1719674115. Green open access

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Abstract

Around the time of gastrulation in higher vertebrate embryos, inductive interactions direct cells to form central nervous system (neural plate) or sensory placodes. Grafts of different tissues into the periphery of a chicken embryo elicit different responses: Hensen’s node induces a neural plate whereas the head mesoderm induces placodes. How different are these processes? Transcriptome analysis in time course reveals that both processes start by induction of a common set of genes, which later diverge. These genes are remarkably similar to those induced by an extraembryonic tissue, the hypoblast, and are normally expressed in the pregastrulation stage epiblast. Explants of this epiblast grown in the absence of further signals develop as neural plate border derivatives and eventually express lens markers. We designate this state as “preborder”; its transcriptome resembles embryonic stem cells. Finally, using sequential transplantation experiments, we show that the node, head mesoderm, and hypoblast are interchangeable to begin any of these inductions while the final outcome depends on the tissue emitting the later signals.

Type: Article
Title: Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells
Open access status: An open access version is available from UCL Discovery
DOI: 10.1073/pnas.1719674115
Publisher version: https://doi.org/10.1073/pnas.1719674115
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: embryonic induction, organizer, gastrulation, neurulation, patterning
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10042839
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