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Parity, breastfeeding and risk of coronary heart disease: A pan-European case-cohort study

Peters, SAE; van der Schouw, YT; Wood, AM; Sweeting, MJ; Moons, KGM; Weiderpass, E; Arriola, L; ... Butterworth, AS; + view all (2016) Parity, breastfeeding and risk of coronary heart disease: A pan-European case-cohort study. European Journal of Preventive Cardiology , 23 (16) pp. 1755-1765. 10.1177/2047487316658571. Green open access

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Abstract

OBJECTIVE: There is uncertainty about the direction and magnitude of the associations between parity, breastfeeding and the risk of coronary heart disease (CHD). We examined the separate and combined associations of parity and breastfeeding practices with the incidence of CHD later in life among women in a large, pan-European cohort study. METHODS: Data were used from European Prospective Investigation into Cancer and Nutrition (EPIC)-CVD, a case–cohort study nested within the EPIC prospective study of 520,000 participants from 10 countries. Information on reproductive history was available for 14,917 women, including 5138 incident cases of CHD. Using Prentice-weighted Cox regression separately for each country followed by a random-effects meta-analysis, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD, after adjustment for age, study centre and several socioeconomic and biological risk factors. RESULTS: Compared with nulliparous women, the adjusted HR was 1.19 (95% CI: 1.01–1.41) among parous women; HRs were higher among women with more children (e.g., adjusted HR: 1.95 (95% CI: 1.19–3.20) for women with five or more children). Compared with women who did not breastfeed, the adjusted HR was 0.71 (95% CI: 0.52–0.98) among women who breastfed. For childbearing women who never breastfed, the adjusted HR was 1.58 (95% CI: 1.09–2.30) compared with nulliparous women, whereas for childbearing women who breastfed, the adjusted HR was 1.19 (95% CI: 0.99–1.43). CONCLUSION: Having more children was associated with a higher risk of CHD later in life, whereas breastfeeding was associated with a lower CHD risk. Women who both had children and breastfed did have a non-significantly higher risk of CHD.

Type: Article
Title: Parity, breastfeeding and risk of coronary heart disease: A pan-European case-cohort study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/2047487316658571
Publisher version: http://dx.doi.org/10.1177/2047487316658571
Language: English
Additional information: © The European Society of Cardiology 2016. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Cardiovascular System & Cardiology, Parity, breastfeeding, Women, coronary heart disease, MATERNAL CARDIOVASCULAR-DISEASE, LIFE-STYLE, LACTATION, WOMEN, MORTALITY, DURATION, PREGNANCY, NUMBER, HEALTH, CANCER
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/10042801
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