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Brownian Dynamics of Electrostatically Adhering Small Vesicles to a Membrane Surface Induces Domains and Probes Viscosity

Tabaei, SR; Gillissen, JJJ; Kim, MC; Ho, JCS; Liedberg, B; Parikh, AN; Cho, N-J; (2016) Brownian Dynamics of Electrostatically Adhering Small Vesicles to a Membrane Surface Induces Domains and Probes Viscosity. Langmuir , 32 (21) pp. 5445-5450. 10.1021/acs.langmuir.6b00985. Green open access

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Abstract

Using single-particle tracking, we investigate the interaction of small unilamellar vesicles (SUVs) that are electrostatically tethered to the freestanding membrane of a giant unilamellar vesicle (GUV). We find that the surface mobility of the GUV-riding SUVs is Brownian, insensitive to the bulk viscosity, vesicle size, and vesicle fluidity but strongly altered by the viscosity of the underlying membrane. Analyzing the diffusional behavior of SUVs within the Saffman–Delbrück model for the dynamics of membrane inclusions supports the notion that the mobility of the small vesicles is coupled to that of dynamically induced lipid clusters within the target GUV membrane. The reversible binding also offers a nonperturbative means for measuring the viscosity of biomembranes, which is an important parameter in cell physiology and function.

Type: Article
Title: Brownian Dynamics of Electrostatically Adhering Small Vesicles to a Membrane Surface Induces Domains and Probes Viscosity
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acs.langmuir.6b00985
Publisher version: http://doi.org/10.1021/acs.langmuir.6b00985
Language: English
Additional information: Copyright © 2016 American Chemical Society. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Physical Sciences, Technology, Chemistry, Multidisciplinary, Chemistry, Physical, Materials Science, Multidisciplinary, Chemistry, Materials Science, SINGLE-PARTICLE TRACKING, LIPID-BILAYERS, NANOPARTICLE TRACKING, SUPPORTED BILAYERS, MODEL MEMBRANE, DIFFUSION, FLUID, ADHESION, SPECTROSCOPY, CHOLESTEROL
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10042695
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