Agrawal, R;
Joachim, N;
Li, L-J;
Lee, J;
Agarwal, A;
Sim, DA;
Keane, PA;
... Pavesio, CE; + view all
(2016)
Assessment of retinal vascular calibres as a biomarker of disease activity in birdshot chorioretinopathy.
Acta Ophthalmologica
, 95
(2)
e113-e118.
10.1111/aos.13156.
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Abstract
Purpose Birdshot chorioretinopathy (BCR) is a potentially blinding ocular disorder involving the retinal vasculature and choroid without any systemic manifestations. The objective of the study was to describe vascular calibre changes in BCR and analyse the possibility of this optical biomarker for staging and monitoring disease activity in BCR. Methods This retrospective case–control study at a tertiary referral eye centre in the UK included 33 eyes from 21 patients with BCR and equal number of eyes from control subjects. Diagnosis of BCR was confirmed on fundus fluorescein and indocyanine green angiography. Vascular calibres were measured using validated semiautomated software. Results Patients with BCR had smaller retinal venular calibres central retinal venular equivalent (CRVE) than controls (211.3 versus 227.9 μm, p = 0.008). After adjusting for variables, the difference between the two groups for CRVE at baseline was statistically significant based on two different analysis methods. Central retinal venular equivalent (CRVE) was lower at the 6-month follow-up visit (206.2 versus 213.8 μm, p-value = 0.03), and arteriole-to-venule ratio was larger (0.74 versus 0.71, p = 0.04) in subjects with BCR. Arteriolar calibre (CRAE) remained the same. Conclusion This study provides novel insight into the pattern of vascular involvement in BCR. There was significant difference in the CRVE in patients with BCR. More studies are needed to correlate this data with visual function and treatment outcome and to validate the findings.
| Type: | Article |
|---|---|
| Title: | Assessment of retinal vascular calibres as a biomarker of disease activity in birdshot chorioretinopathy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/aos.13156 |
| Publisher version: | https://doi.org/10.1111/aos.13156 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Ophthalmology, birdshot chorioretinopathy, chorioretinitis, propensity score, retinal vessel calibre, uveitis, vasculitis, DIABETIC-RETINOPATHY, VESSEL CALIBER, PROGRESSION, RISK, EYE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10042599 |
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