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New Perspectives in Epilepsy Neuropathology

Thom, M; (2018) New Perspectives in Epilepsy Neuropathology. Neuropathology and Applied Neurobiology , 44 (1) pp. 3-5. 10.1111/nan.12464. Green open access

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Abstract

As epilepsy surgery programmes commenced in the 1950s, many eminent neuropathologists embraced the opportunity to study the varied lesions identified in relation to electroencephalography, neuroimaging, psychometry as well as outcome following removal of what was termed the 'alien' brain tissue [1-3]. Beyond their insightful and meticulous histological descriptions, they began to address the questions of what caused these lesions, how they gave rise to epilepsy (the processes of 'epileptogensis') and how they related to other co-morbidities or mortality associated with epilepsy. Now in 2018 we have built on these foundations and, through the evidence amassed from decades of experience, there is greater confidence that resective surgery is a current treatment of choice in selected patients with refractory focal epilepsies.

Type: Article
Title: New Perspectives in Epilepsy Neuropathology
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/nan.12464
Publisher version: http://dx.doi.org/10.1111/nan.12464
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/10042508
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