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Molecular characteristics of long-term epilepsy-associated tumours (LEATs) and mechanisms for tumour-related epilepsy (TRE)

Stone, TJ; Rowell, R; Jayasekera, BAP; Cunningham, MO; Jacques, TS; (2018) Molecular characteristics of long-term epilepsy-associated tumours (LEATs) and mechanisms for tumour-related epilepsy (TRE). Neuropathology and Applied Neurobiology , 44 (1) pp. 56-69. 10.1111/nan.12459. Green open access

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Abstract

Brain tumours are the second most common cause of seizures identified in epilepsy surgical series. While any tumour involving the brain has the potential to cause seizures, specific subtypes are more frequently associated with epilepsy. Tumour-related epilepsy has a profound impact on patients with brain tumours and these seizures are often refractory to anti-epileptic treatments, resulting in long-term disability and patient morbidity. Despite the drastic impact epilepsy-associated tumours have on patients, they have not traditionally enjoyed as much attention as more malignant neoplasms. However, recently a number of developments have been achieved towards furthering our understanding of the molecular and developmental backgrounds of specific epilepsy associated tumours. In addition, the past decade has seen an expansion in the literature on the pathophysiology of tumour-related epilepsy. In this review, we aim to summarise the mechanisms by which tumours may cause seizures and detail recent data regarding the pathogenesis of specific developmental epilepsy-associated tumours. This article is protected by copyright. All rights reserved.

Type: Article
Title: Molecular characteristics of long-term epilepsy-associated tumours (LEATs) and mechanisms for tumour-related epilepsy (TRE)
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/nan.12459
Publisher version: https://doi.org/10.1111/nan.12459
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: LEAT, Dysembryoplastic neuroepithelial tumour, Epilepsy, Ganglioglioma, Glioneuronal tumour
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10042446
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