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Molecular characterization of a human G20P[28] rotavirus a strain with multiple genes related to bat rotaviruses

Esona, MD; Roy, S; Rungsrisuriyachai, K; Gautam, R; Hermelijn, S; Rey-Benito, G; Bowen, MD; (2018) Molecular characterization of a human G20P[28] rotavirus a strain with multiple genes related to bat rotaviruses. Infection, Genetics and Evolution , 57 pp. 166-170. 10.1016/j.meegid.2017.11.025. Green open access

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Abstract

Group A rotaviruses are the major cause of severe gastroenteritis in the young of mammals and birds. This report describes characterization of an unusual G20P[28] rotavirus strain detected in a 24 month old child from Suriname. Genomic sequence analyses revealed that the genotype constellation of the Suriname strain RVA/Human-wt/SUR/2014735512/2013/G20P[28] was G20-P[28]-I13-R13-C13-M12-A23-N13-T15-E20-H15. Genes VP1, VP2, VP3, NSP1, NSP2, NSP3, NSP4 and NSP5 were recently assigned novel genotypes by the Rotavirus Classification Working Group (RCWG). Three of the 11 gene segments (VP7, VP4, VP6) were similar to cognate gene sequences of bat-like human rotavirus strain Ecu534 from Ecuador and the VP7, NSP3 and NSP5 gene segments of strain RVA/Human-wt/SUR/2014735512/2013/G20P[28] were found to be closely related to gene sequences of bat rotavirus strain 3081/BRA detected in Brazil. Although distantly related, the VP1 gene of the study strain and bat strain BatLi09 detected in Cameroon in 2014 are monophyletic. The NSP1 gene was found to be most closely related to human strain QUI-35-F5 from Brazil. These findings suggest that strain RVA/Human-wt/SUR/2014735512/2013/G20P[28] represents a zoonotic infection from a bat host.

Type: Article
Title: Molecular characterization of a human G20P[28] rotavirus a strain with multiple genes related to bat rotaviruses
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.meegid.2017.11.025
Publisher version: https://doi.org/10.1016/j.meegid.2017.11.025
Language: English
Additional information: Published by Elsevier B.V. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Rotavirus, G20P[28], Novel genotypes, Suriname
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10042442
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