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Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities

Ong, S-B; Hernández-Reséndiz, S; Crespo-Avilan, GE; Mukhametshina, RT; Kwek, X-Y; Cabrera-Fuentes, HA; Hausenloy, DJ; (2018) Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities. Pharmacology & Therapeutics , 186 pp. 73-87. 10.1016/j.pharmthera.2018.01.001. Green open access

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Abstract

Acute myocardial infarction (AMI) and the heart failure that often follows, are major causes of death and disability worldwide. As such, new therapies are required to limit myocardial infarct (MI) size, prevent adverse left ventricular (LV) remodeling, and reduce the onset of heart failure following AMI. The inflammatory response to AMI, plays a critical role in determining MI size, and a persistent pro-inflammatory reaction can contribute to adverse post-MI LV remodeling, making inflammation an important therapeutic target for improving outcomes following AMI. In this article, we provide an overview of the multiple players (and their dynamic roles) involved in the complex inflammatory response to AMI and subsequent LV remodeling, and highlight future opportunities for targeting inflammation as a therapeutic strategy for limiting MI size, preventing adverse LV remodeling, and reducing heart failure in AMI patients.

Type: Article
Title: Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.pharmthera.2018.01.001
Publisher version: https://doi.org/10.1016/j.pharmthera.2018.01.001
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
Keywords: Acute myocardial infarction, Acute myocardial ischemia and reperfusion injury, Chemokines, Cytokines, Dendritic cells, Inflammation, Innate immunity, Lymphocytes, Macrophages, Monocytes
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10042440
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