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Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection

Bell, LCK; Noursadeghi, M; (2018) Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection. [Review]. Nature Reviews Microbiology , 16 (2) pp. 80-90. 10.1038/nrmicro.2017.128. Green open access

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Abstract

Co-infection with Mycobacterium tuberculosis is the leading cause of death in individuals infected with HIV-1. It has long been known that HIV-1 infection alters the course of M. tuberculosis infection and substantially increases the risk of active tuberculosis (TB). It has also become clear that TB increases levels of HIV-1 replication, propagation and genetic diversity. Therefore, co-infection provides reciprocal advantages to both pathogens. In this Review, we describe the epidemiological associations between the two pathogens, selected interactions of each pathogen with the host and our current understanding of how they affect the pathogenesis of TB and HIV-1/AIDS in individuals with co-infections. We evaluate the mechanisms and consequences of HIV-1 depletion of T cells on immune responses to M. tuberculosis. We also discuss the effect of HIV-1 infection on the control of M. tuberculosis by macrophages through phagocytosis, autophagy and cell death, and we propose models by which dysregulated inflammatory responses drive the pathogenesis of TB and HIV-1/AIDS.

Type: Article
Title: Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nrmicro.2017.128
Publisher version: http://doi.org/10.1038/nrmicro.2017.128
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Bacterial pathogenesis, HIV infections, Immunopathogenesis, Tuberculosis, Viral pathogenesis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10042404
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