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Prevention and treatment of hepatic encephalopathy: Focusing on gut microbiota

Garcovich, M; Zocco, MA; Roccarina, D; Ponziani, FR; Gasbarrini, A; (2012) Prevention and treatment of hepatic encephalopathy: Focusing on gut microbiota. World Journal of Gastroenterology , 18 (46) p. 6693. 10.3748/wjg.v18.i46.6693. Green open access

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Abstract

The gut flora plays an important role in the pathogenesis of the complications of cirrhosis. Hepatic encephalopathy (HE) represents a broad continuum of neuropsychological dysfunction in patients with acute or chronic liver disease and/or porto-systemic shunting of blood flow and it manifests with progressive deterioration of the superior neurological functions. The pathophysiology of this disease is complex, as it involves overproduction and reduced metabolism of various neurotoxins, particularly ammonia. Management of HE is diversified and requires several steps: elimination of precipitating factors, removal of toxins, proper nutritional support, modulation of resident fecal flora and downregulation of systemic and gut-derived inflammation. This review will provide an overview of gut barrier function and the influence of gut-derived factors on HE, focusing on the role of gut microbiota in the pathogenesis of HE and the recent literature findings on its therapeutic manipulation.

Type: Article
Title: Prevention and treatment of hepatic encephalopathy: Focusing on gut microbiota
Open access status: An open access version is available from UCL Discovery
DOI: 10.3748/wjg.v18.i46.6693
Publisher version: http://dx.doi.org/10.3748/wjg.v18.i46.6693
Language: English
Additional information: Articles published by this open-access journal are distributed under the terms of the Creative Commons Attribution-Noncommercial (CC BY-NC 4.0) License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.
Keywords: Hepatic encephalopathy; Gut microbiota; Cirrhosis; Non-absorbable disaccharides; Rifaximin
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10042238
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