Zhao, J;
Lichman, BR;
Ward, JM;
Hailes, HC;
(2018)
One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues.
Chemical Communications
, 54
(11)
pp. 1323-1326.
10.1039/c7cc08024g.
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Abstract
Chemoenzymatic reaction cascades can provide access to chiral compounds from low-cost starting materials in one pot. Here we describe one-pot asymmetric routes to tetrahydroisoquinoline alkaloids (THIAs) using the Pictet-Spenglerase norcoclaurine synthase (NCS) followed by a cyclisation, to give alkaloids with two new heterocyclic rings. These reactions operated with a high atom economy to generate THIAs in high yields.
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