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Transplanted human thymus slices induce and support T‐cell development in mice after cryopreservation

Ross, S; Cheung, M; Lau, C-I; Sebire, N; Burch, M; Kilbride, P; Fuller, B; ... Crompton, T; + view all (2018) Transplanted human thymus slices induce and support T‐cell development in mice after cryopreservation. European Journal of Immunology , 48 (4) pp. 716-719. 10.1002/eji.201747193. Green open access

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Abstract

Here we show that slices of human thymus tissue that have been frozen and thawed can induce and support T‐cell development when transplanted into nude mice. Infants born without a thymus require urgent treatment to reconstitute T‐cell immunity 1. Thymus tissue is removed from infants during cardiac surgery, to allow access to the heart. This discarded thymus tissue can be transplanted into athymic infants 2-4. Slices of thymus tissue are transplanted into the thigh, after a 2‐ to 3‐week culture period to deplete thymocytes. This procedure is life‐saving, but recipients have low T‐cell counts, and may develop autoimmunity. It is not possible to attempt to MHC‐match transplants between donor and recipient because of the urgency of performing the procedure 2, 3, 5. As delays in thymus transplantation could be life‐threatening, the procedure would be improved if it were possible to freeze thymus slices for transplantation. Cryopreservation would also open up the possibility of partial MHC‐matching.

Type: Article
Title: Transplanted human thymus slices induce and support T‐cell development in mice after cryopreservation
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/eji.201747193
Publisher version: https://doi.org/10.1002/eji.201747193
Language: English
Additional information: © 2018 The Authors. European Journal of Immunology published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
Keywords: Clinical immunology, Cryopreservation, Thymopoiesis, Thymus transplantation, Transplantation
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10041665
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