Collinge, J;
Purro, SA;
Nicoll, A;
(2018)
Prion Protein as a Toxic Acceptor of Amyloid-β Oligomers.
Biological Psychiatry
, 83
(4)
pp. 358-368.
10.1016/j.biopsych.2017.11.020.
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Abstract
The initial report that cellular prion protein (PrPC) mediates toxicity of Amyloid-β (Aβ) species linked to Alzheimer’s disease was initially treated with scepticism, but growing evidence supports this claim. That there is a high-affinity interaction is now clear and its molecular basis is being unravelled whilst recent studies have identified possible down-stream toxic mechanisms. Determination of the clinical significance of such interactions between PrPC and disease-associated Aβ species will require experimental medicine studies in humans. Compounds that inhibit PrP-dependent Aβ toxicity are starting to be trialled in humans and, although it is clear that only a fraction of Alzheimer’s disease toxicity could be governed by PrPC, a partial but still therapeutically useful role in human disease may soon be testable.
| Type: | Article |
|---|---|
| Title: | Prion Protein as a Toxic Acceptor of Amyloid-β Oligomers |
| Location: | US |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.biopsych.2017.11.020 |
| Publisher version: | http://doi.org/10.1016/j.biopsych.2017.11.020 |
| Language: | English |
| Additional information: | © 2017 Published by Elsevier Inc on behalf of Society of Biological Psychiatry. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Prion, Amyloid, Alzheimer's disease, Oligomers, Neurodegeneration, Therapeutics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases > MRC Prion Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10041403 |
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