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Prion Protein as a Toxic Acceptor of Amyloid-β Oligomers

Collinge, J; Purro, SA; Nicoll, A; (2018) Prion Protein as a Toxic Acceptor of Amyloid-β Oligomers. Biological Psychiatry , 83 (4) pp. 358-368. 10.1016/j.biopsych.2017.11.020. Green open access

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Abstract

The initial report that cellular prion protein (PrPC) mediates toxicity of Amyloid-β (Aβ) species linked to Alzheimer’s disease was initially treated with scepticism, but growing evidence supports this claim. That there is a high-affinity interaction is now clear and its molecular basis is being unravelled whilst recent studies have identified possible down-stream toxic mechanisms. Determination of the clinical significance of such interactions between PrPC and disease-associated Aβ species will require experimental medicine studies in humans. Compounds that inhibit PrP-dependent Aβ toxicity are starting to be trialled in humans and, although it is clear that only a fraction of Alzheimer’s disease toxicity could be governed by PrPC, a partial but still therapeutically useful role in human disease may soon be testable.

Type: Article
Title: Prion Protein as a Toxic Acceptor of Amyloid-β Oligomers
Location: US
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.biopsych.2017.11.020
Publisher version: http://doi.org/10.1016/j.biopsych.2017.11.020
Language: English
Additional information: © 2017 Published by Elsevier Inc on behalf of Society of Biological Psychiatry. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Prion, Amyloid, Alzheimer's disease, Oligomers, Neurodegeneration, Therapeutics
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases > MRC Prion Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10041403
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