UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Bi‐exponential 23Na T2* component analysis in the human brain

Riemer, F; Solanky, BS; Wheeler-Kingshott, CAM; Golay, X; (2018) Bi‐exponential 23Na T2* component analysis in the human brain. NMR in Biomedicine , 31 (5) 10.1002/nbm.3899. Green open access

[thumbnail of Golay_T2paper_clean_V3wfigures.pdf]
Preview
Text
Golay_T2paper_clean_V3wfigures.pdf - Accepted Version

Download (825kB) | Preview

Abstract

The purpose of this study was to measure the sodium transverse relaxation time T2* in the healthy human brain. Five healthy subjects were scanned with 18 echo times (TEs) as short as 0.17 ms. T2* values were fitted on a voxel‐by‐voxel basis using a bi‐exponential model. Data were also analysed using a continuous distribution fit with a region of interest‐based inverse Laplace transform. Average T2* values were 3.4 ± 0.2 ms and 23.5 ± 1.8 ms in white matter (WM) for the short and long components, respectively, and 3.9 ± 0.5 ms and 26.3 ± 2.6 ms in grey matter (GM) for the short and long components, respectively, using the bi‐exponential model. Continuous distribution fits yielded results of 3.1 ± 0.3 ms and 18.8 ± 3.2 ms in WM for the short and long components, respectively, and 2.9 ± 0.4 ms and 17.2 ± 2 ms in GM for the short and long components, respectively. 23Na T2* values of the brain for the short and long components for various anatomical locations using ultra‐short TEs are presented for the first time.

Type: Article
Title: Bi‐exponential 23Na T2* component analysis in the human brain
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/nbm.3899
Publisher version: https://doi.org/10.1002/nbm.3899
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: 23Na, neuro, non‐Cartesian, relaxometry, sodium, UTE
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10041191
Downloads since deposit
227Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item