Heller, JP;
Rusakov, DA;
(2017)
The Nanoworld of the Tripartite Synapse: Insights from Super-Resolution Microscopy.
Frontiers in Cellular Neuroscience
, 11
(374)
10.3389/fncel.2017.00374.
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Abstract
Synaptic connections between individual nerve cells are fundamental to the process of information transfer and storage in the brain. Over the past decades a third key partner of the synaptic machinery has been unveiled: ultrathin processes of electrically passive astroglia which often surround pre- and postsynaptic structures. The recent advent of super-resolution (SR) microscopy has begun to uncover the dynamic nanoworld of synapses and their astroglial environment. Here we overview and discuss the current progress in our understanding of the synaptic nanoenvironment, as gleaned from the imaging methods that go beyond the diffraction limit of conventional light microscopy. We argue that such methods are essential to achieve a new level of comprehension pertinent to the principles of signal integration in the brain.
| Type: | Article |
|---|---|
| Title: | The Nanoworld of the Tripartite Synapse: Insights from Super-Resolution Microscopy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fncel.2017.00374 |
| Publisher version: | https://doi.org/10.3389/fncel.2017.00374 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, synapses, astroglia, tripartite synapse, super-resolution microscopy, plasticity, AMPA RECEPTOR TRAFFICKING, STRUCTURED ILLUMINATION MICROSCOPY, OPTICAL RECONSTRUCTION MICROSCOPY, SINGLE-PARTICLE TRACKING, STED-MICROSCOPY, FLUORESCENCE MICROSCOPY, DENDRITIC SPINES, POSTSYNAPTIC DENSITY, STIMULATED-EMISSION, IMAGING REVEALS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10040814 |
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