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Local Hemodynamic Forces After Stenting Implications on Restenosis and Thrombosis

Ng, J; Bourantas, CV; Torii, R; Ang, HY; Tenekecioglu, E; Serruys, PW; Foin, N; (2017) Local Hemodynamic Forces After Stenting Implications on Restenosis and Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology , 37 (12) pp. 2231-2242. 10.1161/ATVBAHA.117.309728. Green open access

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Abstract

Local hemodynamic forces are well-known to modulate atherosclerotic evolution, which remains one of the largest cause of death worldwide. Percutaneous coronary interventions with stent implantation restores blood flow to the downstream myocardium and is only limited by stent failure caused by restenosis, stent thrombosis, or neoatherosclerosis. Cumulative evidence has shown that local hemodynamic forces affect restenosis and the platelet activation process, modulating the pathophysiological mechanisms that lead to stent failure. This article first covers the pathophysiological mechanisms through which wall shear stress regulates arterial disease formation/neointima proliferation and the role of shear rate on stent thrombosis. Subsequently, the article reviews the current evidence on (1) the implications of stent design on the local hemodynamic forces, and (2) how stent/scaffold expansion can influence local flow, thereby affecting the risk of adverse events.

Type: Article
Title: Local Hemodynamic Forces After Stenting Implications on Restenosis and Thrombosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1161/ATVBAHA.117.309728
Publisher version: https://doi.org/10.1161/ATVBAHA.117.309728
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Hematology, Peripheral Vascular Disease, Cardiovascular System & Cardiology, hemodynamics, percutaneous coronary intervention, stents, thrombosis, ENDOTHELIAL SHEAR-STRESS, OPTICAL COHERENCE TOMOGRAPHY, BIORESORBABLE VASCULAR SCAFFOLD, CORONARY-ARTERY-DISEASE, DRUG-ELUTING STENTS, VON-WILLEBRAND-FACTOR, MULTI-IMAGING MODALITY, BARE-METAL STENTS, IN-VIVO, INTRAVASCULAR ULTRASOUND
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10040648
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