Clark, KEN;
Giles, I;
(2018)
Antiphospholipid syndrome.
Medicine
, 46
(2)
pp. 118-125.
10.1016/j.mpmed.2017.11.006.
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Abstract
Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia characterized by venous or arterial thrombosis, and/or pregnancy loss or complications in the presence of persistently positive antiphospholipid antibodies. Patients can also develop other organ involvement, referred to as non-criteria manifestations, including livedo reticularis, thrombocytopenia and nephropathy. Non-thrombotic inflammatory mechanisms are increasingly identified in the pathogenesis of APS, alongside a recognition that obstetric APS may be a specific subset of APS. Treatment remains focused on lifelong anticoagulation and prevention of further thrombosis or obstetric complications. Identification of novel mechanisms is, however, leading the development of diagnostic tests and more targeted therapies to improve disease management.
| Type: | Article |
|---|---|
| Title: | Antiphospholipid syndrome |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.mpmed.2017.11.006 |
| Publisher version: | https://doi.org/10.1016/j.mpmed.2017.11.006 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | β2-Glycoprotein-1 antibodies, anticardiolipin antibodies, anticoagulation, antiphospholipid syndrome, complement, lupus anticoagulant, MRC, Pobstetric morbiditythrombosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10040540 |
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