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Antiphospholipid syndrome

Clark, KEN; Giles, I; (2018) Antiphospholipid syndrome. Medicine , 46 (2) pp. 118-125. 10.1016/j.mpmed.2017.11.006. Green open access

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Abstract

Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia characterized by venous or arterial thrombosis, and/or pregnancy loss or complications in the presence of persistently positive antiphospholipid antibodies. Patients can also develop other organ involvement, referred to as non-criteria manifestations, including livedo reticularis, thrombocytopenia and nephropathy. Non-thrombotic inflammatory mechanisms are increasingly identified in the pathogenesis of APS, alongside a recognition that obstetric APS may be a specific subset of APS. Treatment remains focused on lifelong anticoagulation and prevention of further thrombosis or obstetric complications. Identification of novel mechanisms is, however, leading the development of diagnostic tests and more targeted therapies to improve disease management.

Type: Article
Title: Antiphospholipid syndrome
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mpmed.2017.11.006
Publisher version: https://doi.org/10.1016/j.mpmed.2017.11.006
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: β2-Glycoprotein-1 antibodies, anticardiolipin antibodies, anticoagulation, antiphospholipid syndrome, complement, lupus anticoagulant, MRC, Pobstetric morbiditythrombosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10040540
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