UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Predictors of Age of Diagnosis and Survival of Alzheimer's Disease in Down Syndrome

Sinai, A; Mokrysz, C; Bernal, J; Bohnen, I; Bonell, S; Courtenay, K; Dodd, K; ... Strydom, A; + view all (2017) Predictors of Age of Diagnosis and Survival of Alzheimer's Disease in Down Syndrome. Journal of Alzheimer's Disease , 61 (2) pp. 717-728. 10.3233/JAD-170624. Green open access

[img]
Preview
Text
Predictors of age of diagnosis and survival of Alzheimers disease in Down syndrome - final with minor revisions2 no codes.pdf - Accepted version

Download (705kB) | Preview

Abstract

BACKGROUND: People with Down syndrome (DS) are an ultra-high risk population for Alzheimer's disease (AD). Understanding the factors associated with age of onset and survival in this population could highlight factors associated with modulation of the amyloid cascade. OBJECTIVE: This study aimed to establish the typical age at diagnosis and survival associated with AD in DS and the risk factors associated with these. METHODS: Data was obtained from the Aging with Down Syndrome and Intellectual Disabilities (ADSID) research database, consisting of data extracted from clinical records of patients seen by Community Intellectual Disability Services (CIDS) in England. Survival times when considering different risk factors were calculated. RESULTS: The mean age of diagnosis was 55.80 years, SD 6.29. Median survival time after diagnosis was 3.78 years, and median age at death was approximately 60 years. Survival time was associated with age of diagnosis, severity of intellectual disability, living status, anti-dementia medication status, and history of epilepsy. Age at diagnosis and treatment status remained predictive of survival time following adjustment. CONCLUSION: This study provides the best estimate of survival in dementia within the DS population to date, and is in keeping with previous estimates from smaller studies in the DS population. This study provides important estimates and insights into possible predictors of survival and age of diagnosis of AD in adults with DS, which will inform selection of participants for treatment trials in the future.

Type: Article
Title: Predictors of Age of Diagnosis and Survival of Alzheimer's Disease in Down Syndrome
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.3233/JAD-170624
Publisher version: https://doi.org/10.3233/JAD-170624
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer’s disease, Down syndrome, dementia, mental retardation, survival
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10040526
Downloads since deposit
113Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item