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Covalently attached anti-microbial surfaces using BODIPY: Improving efficiency and effectiveness

Peveler, WJ; Noimark, S; Al-Azawi, H; Hwang, GB; Crick, CR; Allan, E; Edel, JB; ... Parkin, IP; + view all (2017) Covalently attached anti-microbial surfaces using BODIPY: Improving efficiency and effectiveness. ACS Applied Materials & Interfaces , 10 (1) pp. 98-104. 10.1021/acsami.7b13273. Green open access

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Abstract

The development of photo-activated antimicrobial surfaces that kill pathogens through the production of singlet oxygen has proved very effective in recent years, with applications in medical devices and hospital touch surfaces, to improve patient safety and well-being. However, many of these surfaces require a swell-encapsulation-shrink strategy to incorporate the photoactive agents in a polymer matrix, and this is resource intensive, given that only the surface fraction of the agent is active against bacteria. Furthermore, there is a risk that the agent will leach from the polymer, and thus raises issues of biocompatibility and patient safety. Here we describe a more efficient method of fabricating a silicone material with a covalently attached monolayer of photo-activating agent that uses heavy-atom triplet sensitization for improved singlet oxygen generation and corresponding antimicrobial activity. We use boron-dipyrromethane (BODIPY) with a reactive end group and incorporated Br atoms, covalently attached to polydimethylsiloxane (PDMS). We demonstrate the efficacy of this material in producing singlet oxygen and killing S. aureus and suggest how it might be easily modifiable for future antimicrobial surface development.

Type: Article
Title: Covalently attached anti-microbial surfaces using BODIPY: Improving efficiency and effectiveness
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsami.7b13273
Publisher version: http://doi.org/10.1021/acsami.7b13273
Language: English
Additional information: This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Keywords: BODIPY, antimicrobial, PDMS, singlet oxygen, fluorescence microscopy
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10040417
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