Froudist-Walsh, S;
Bloomfield, MA;
Veronese, M;
Kroll, J;
Karolis, VR;
Jauhar, S;
Bonoldi, I;
... Howes, O; + view all
(2017)
The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life.
eLife
, 6
, Article e29088. 10.7554/eLife.29088.
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Abstract
Perinatal brain injuries, including hippocampal lesions, cause lasting changes in dopamine function in rodents, but it is not known if this occurs in humans. We compared adults who were born very preterm with perinatal brain injury to those born very preterm without perinatal brain injury, and age-matched controls born at full term using [18F]-DOPA PET and structural MRI. Dopamine synthesis capacity was reduced in the perinatal brain injury group relative to those without brain injury (Cohen's d = 1.36, p=0.02) and the control group (Cohen's d = 1.07, p=0.01). Hippocampal volume was reduced in the perinatal brain injury group relative to controls (Cohen's d = 1.17, p=0.01) and was positively correlated with striatal dopamine synthesis capacity (r = 0.344, p=0.03). This is the first evidence in humans linking neonatal hippocampal injury to adult dopamine dysfunction, and provides a potential mechanism linking early life risk factors to adult mental illness.
| Type: | Article |
|---|---|
| Title: | The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7554/eLife.29088 |
| Publisher version: | http://dx.doi.org/10.7554/eLife.29088 |
| Language: | English |
| Additional information: | Copyright © 2017, Froudist-Walsh et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
| Keywords: | brain injury, brain volume, dopamine, human, imaging, neuroscience, preterm |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10040008 |
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