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Hippocampal CA1 Activity Correlated with the Distance to the Goal and Navigation Performance

Spiers, HJ; Olafsdottir, HF; Lever, C; (2017) Hippocampal CA1 Activity Correlated with the Distance to the Goal and Navigation Performance. Hippocampus 10.1002/hipo.22813. (In press). Green open access

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Abstract

Coding the distance to a future goal is an important function of a neural system supporting navigation. While some evidence indicates the hippocampus increases activity with proximity to the goal, others have found activity to decreases with proximity. To explore goal distance coding in the hippocampus we recorded from CA1 hippocampal place cells in rats as they navigated to learned goals in an event arena with a win-stay lose-shift rule. CA1 activity was positively correlated with the distance - decreasing with proximity to the goal. The stronger the correlation between distance to the goal and CA1 activity, the more successful navigation was in a given task session. Acceleration, but not speed, was also correlated with the distance to the goal. However, the relationship between CA1 activity and navigation performance was independent of variation in acceleration and variation in speed. These results help clarify the situations in which CA1 activity encodes navigationally relevant information and the extent to which it relates to behavior. This article is protected by copyright. All rights reserved.

Type: Article
Title: Hippocampal CA1 Activity Correlated with the Distance to the Goal and Navigation Performance
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/hipo.22813
Publisher version: http://dx.doi.org/10.1002/hipo.22813
Language: English
Additional information: © 2017 The Authors. Hippocampus Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10039938
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