UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Computational aspects of parvalbumin-positive interneuron function

Cornford, Jonathan; (2017) Computational aspects of parvalbumin-positive interneuron function. Doctoral thesis (Ph.D), UCL (University College London). Green open access

[thumbnail of jcornford_thesis.pdf]
Preview
Text
jcornford_thesis.pdf - Accepted Version

Download (29MB) | Preview

Abstract

The activity of neurons is dependent on the manner in which they process synaptic inputs from other cells. In the event of clustered synaptic input, neurons can respond in a nonlinear manner through synaptic and dendritic mechanisms. Such mechanisms are well established in principal excitatory neurons throughout the brain, where they increase neuronal computational ability and information storage capacity. In contrast for parvalbumin-positive (PV+) interneurons, the most common cortical class of in- hibitory interneuron, synaptic integration is thought to be either linear or sub-linear in nature, facilitating their role as mediators of precise and fast inhibition. This thesis addresses situations in which PV+ interneurons integrate synaptic inputs in a nonlinear manner, and explores the functions of this synaptic processing. First, I describe a form of cooperative supralinear synaptic integration by local excitatory inputs onto PV+ interneurons, and I extend these results to show how this augments the computational capability of PV+ cells within spiking neuron networks. I also explore the importance of polyamine-modulation of synaptic receptors in mediating sublinear synaptic integration, and discuss how this expands the array of mechanisms known to perform similar functions in PV+ cells. Finally, I present work manipulating PV+ cells experimentally during epilepsy. I consider these findings together with recent scientific advances and suggest how they account for a number of open questions and previously contradictory theories of PV+ interneuron function.

Type: Thesis (Doctoral)
Qualification: Ph.D
Title: Computational aspects of parvalbumin-positive interneuron function
Event: UCL (University College London)
Open access status: An open access version is available from UCL Discovery
Language: English
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/10039927
Downloads since deposit
69Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item