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A Global Characterisation of the Archaeal Transcription Machinery

Smollett, K; Blombach, F; Fouqueau, T; Werner, F; (2017) A Global Characterisation of the Archaeal Transcription Machinery. In: Clouet-d'Orval, B, (ed.) RNA Metabolism and Gene Expression in Archaea. (pp. 1-26). Springer: Cham, Switzerland. Green open access

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Abstract

Archaea employ a eukaryote-like transcription apparatus to transcribe a bacteria-like genome; while the RNA polymerase, basal factors and promoter elements mirror the eukaryotic RNA polymerase II system, archaeal genomes are densely packed with genes organised into multicistronic transcription units. The molecular mechanisms of archaeal transcription have been studied and characterised in great detail in vitro, but until recently relatively little was known about its global characteristics. In this chapter we discuss an integrated view of transcription from the molecular to the global level. Systems biology approaches have provided compelling insights into promoter and terminator DNA elements, the genome-wide distribution of transcription initiation- and elongation factors and RNA polymerase, the archaeal transcriptome and chromatin organisation. Overall these analyses illuminate transcription from a genome-wide perspective and serve as a resource for the community. In addition, Big Data can often validate mechanistic models based on biochemical and structural information, and generate new working hypotheses that can be thoroughly tested and dissected in vitro. This is an exciting time to study gene expression in the archaea since we are at the brink of a comprehensive yet detailed understanding of transcription.

Type: Book chapter
Title: A Global Characterisation of the Archaeal Transcription Machinery
ISBN: 331965795X
ISBN-13: 9783319657950
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-319-65795-0_1
Publisher version: https://doi.org/10.1007/978-3-319-65795-0_1
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10039610
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