UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Repetitive sequences in malaria parasite proteins

Davies, HM; Nofal, SD; McLaughlin, EJ; Osborne, AR; (2017) Repetitive sequences in malaria parasite proteins. FEMS Microbiology Reviews , 41 (6) pp. 923-940. 10.1093/femsre/fux046. Green open access

[img]
Preview
Text
Repeat review rev dep.pdf - Accepted version

Download (3MB) | Preview

Abstract

Five species of parasite cause malaria in humans with the most severe disease caused by Plasmodium falciparum. Many of the proteins encoded in the P. falciparum genome are unusually enriched in repetitive low-complexity sequences containing a limited repertoire of amino acids. These repetitive sequences expand and contract dynamically and are among the most rapidly changing sequences in the genome. The simplest repetitive sequences consist of single amino acid repeats such as poly-asparagine tracts that are found in approximately 25% of P. falciparum proteins. More complex repeats of two or more amino acids are also common in diverse parasite protein families. There is no universal explanation for the occurrence of repetitive sequences and it is possible that many confer no function to the encoded protein and no selective advantage or disadvantage to the parasite. However, there are increasing numbers of examples where repetitive sequences are important for parasite protein function. We discuss the diverse roles of low-complexity repetitive sequences throughout the parasite life cycle, from mediating protein-protein interactions to enabling the parasite to evade the host immune system.

Type: Article
Title: Repetitive sequences in malaria parasite proteins
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/femsre/fux046
Publisher version: https://doi.org/10.1093/femsre/fux046
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Plasmodium falciparum, host-pathogen interaction, low complexity, malaria, protein evolution, protein repeats
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10039569
Downloads since deposit
19Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item