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Light Dominates Peripheral Circadian Oscillations in Drosophila melanogaster During Sensory Conflict

Harper, REF; Ogueta, M; Dayan, P; Stanewsky, R; Albert, JT; (2017) Light Dominates Peripheral Circadian Oscillations in Drosophila melanogaster During Sensory Conflict. Journal of Biological Rhythms , 32 (5) pp. 423-432. 10.1177/0748730417724250. Green open access

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Abstract

In Drosophila, as in other animals, the circadian clock is a singular entity in name and concept only. In reality, clock functions emerge from multiple processes and anatomical substrates. One distinction has conventionally been made between a central clock (in the brain) and peripheral clocks (e.g., in the gut and the eyes). Both types of clock generate robust circadian oscillations, which do not require external input. Furthermore, the phases of these oscillations remain exquisitely sensitive to specific environmental cues, such as the daily changes of light and temperature. When these cues conflict with one another, the central clock displays complex forms of sensory integration; how peripheral clocks respond to conflicting input is unclear. We therefore explored the effects of light and temperature misalignments on peripheral clocks. We show that under conflict, peripheral clocks preferentially synchronize to the light stimulus. This photic dominance requires the presence of the circadian photoreceptor, Cryptochrome.

Type: Article
Title: Light Dominates Peripheral Circadian Oscillations in Drosophila melanogaster During Sensory Conflict
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0748730417724250
Publisher version: https://doi.org/10.1177/0748730417724250
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cryptochrome, Drosophila, circadian entrainment, circadian rhythms, luciferase, multisensory entrainment, period, peripheral clocks, sensory conflict, sensory integration
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Gatsby Computational Neurosci Unit
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/10039346
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