Kalitzeos, A;
Samra, R;
Kasilian, M;
Tee, JJL;
Strampe, M;
Langlo, C;
Webster, AR;
... Michaelides, M; + view all
(2017)
Cellular Imaging Of The Tapetal-like Reflex In Carriers Of RPGR-associated Retinopathy.
Retina
10.1097/IAE.0000000000001965.
(In press).
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CELLULAR_IMAGING_OF_THE_TAPETAL_LIKE_REFLEX_IN.96680.pdf - Published Version Download (1MB) | Preview |
Abstract
PURPOSE: To examine the features of the tapetal-like reflex (TLR) in female carriers of RPGR-associated retinopathy by means of adaptive optics scanning light ophthalmoscopy (AOSLO) and spectral domain optical coherence tomography. METHODS: Nine molecularly confirmed RPGR carriers and three healthy controls underwent ocular examination and the following retinal imaging modalities: color photography, near-infrared reflectance, fundus autofluorescence, spectral domain optical coherence tomography, and AOSLO. After identifying TLR areas across all imaging modalities, normalized local contrast of outer retinal bands on spectral domain optical coherence tomography was calculated and AOSLO-acquired photoreceptor mosaic analysis was performed. RESULTS: Seven carriers had TLR areas, which colocalized with increased rod photoreceptor reflectivity on confocal AOSLO and reduced cone photoreceptor densities. Parafoveal TLR areas also exhibited reduced local contrast (i.e., increased reflectivity) of the outer retinal bands on spectral domain optical coherence tomography (inner segment ellipsoid zone and outer segment interdigitation zone). Healthy controls did not show TLR. CONCLUSION: The cellular resolution provided by AOSLO affords the characterization of the photoreceptor mosaic in RPGR carriers with a TLR. Features revealed include reduced cone densities, increased cone inner segment diameters, and increased rod outer segment reflectivity.
| Type: | Article |
|---|---|
| Title: | Cellular Imaging Of The Tapetal-like Reflex In Carriers Of RPGR-associated Retinopathy |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/IAE.0000000000001965 |
| Publisher version: | http://dx.doi.org/10.1097/IAE.0000000000001965 |
| Language: | English |
| Additional information: | This is an open access article distributed under the Creative Commons Attribution License 4.0 (CC-BY) (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | adaptive optics, carriers, heterozygotes, imaging, retinitis pigmentosa, tapetal-like reflex |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10039328 |
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