UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Adaptive optics imaging of inherited retinal diseases.

Georgiou, M; Kalitzeos, A; Patterson, EJ; Dubra, A; Carroll, J; Michaelides, M; (2018) Adaptive optics imaging of inherited retinal diseases. [Review]. British Journal of Ophthalmology , 102 (8) pp. 1028-1035. 10.1136/bjophthalmol-2017-311328. Green open access

[thumbnail of georgiou17.pdf]
Preview
Text
georgiou17.pdf - Published Version

Download (1MB) | Preview

Abstract

Adaptive optics (AO) ophthalmoscopy allows for non-invasive retinal phenotyping on a microscopic scale, thereby helping to improve our understanding of retinal diseases. An increasing number of natural history studies and ongoing/planned interventional clinical trials exploit AO ophthalmoscopy both for participant selection, stratification and monitoring treatment safety and efficacy. In this review, we briefly discuss the evolution of AO ophthalmoscopy, recent developments and its application to a broad range of inherited retinal diseases, including Stargardt disease, retinitis pigmentosa and achromatopsia. Finally, we describe the impact of this in vivo microscopic imaging on our understanding of disease pathogenesis, clinical trial design and outcome metrics, while recognising the limitation of the small cohorts reported to date.

Type: Article
Title: Adaptive optics imaging of inherited retinal diseases.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/bjophthalmol-2017-311328
Publisher version: http://dx.doi.org/10.1136/bjophthalmol-2017-311328
Language: English
Additional information: © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
Keywords: Genetics, imaging, retina, vision
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10039002
Downloads since deposit
81Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item