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Enhancing Biological and Biomechanical Fixation of Osteochondral Scaffold: A Grand Challenge

Tamaddon, M; Liu, C; (2018) Enhancing Biological and Biomechanical Fixation of Osteochondral Scaffold: A Grand Challenge. In: Oliveira, JM and Pina, S and Reis, RL and San Roman, J, (eds.) Osteochondral Tissue Engineering: Challenges, Current Strategies, and Technological Advances. (pp. 255-298). Springer: Cham, Switzerland. Green open access

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Abstract

Osteoarthritis (OA) is a degenerative joint disease, typified by degradation of cartilage and changes in the subchondral bone, resulting in pain, stiffness and reduced mobility. Current surgical treatments often fail to regenerate hyaline cartilage and result in the formation of fibrocartilage. Tissue engineering approaches have emerged for the repair of cartilage defects and damages to the subchondral bones in the early stage of OA and have shown potential in restoring the joint's function. In this approach, the use of three-dimensional scaffolds (with or without cells) provides support for tissue growth. Commercially available osteochondral (OC) scaffolds have been studied in OA patients for repair and regeneration of OC defects. However, some controversial results are often reported from both clinical trials and animal studies. The objective of this chapter is to report the scaffolds clinical requirements and performance of the currently available OC scaffolds that have been investigated both in animal studies and in clinical trials. The findings have demonstrated the importance of biological and biomechanical fixation of the OC scaffolds in achieving good cartilage fill and improved hyaline cartilage formation. It is concluded that improving cartilage fill, enhancing its integration with host tissues and achieving a strong and stable subchondral bone support for overlying cartilage are still grand challenges for the early treatment of OA.

Type: Book chapter
Title: Enhancing Biological and Biomechanical Fixation of Osteochondral Scaffold: A Grand Challenge
ISBN-13: 978-3-319-76735-2
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-319-76735-2_12
Publisher version: https://doi.org/10.1007/978-3-319-76735-2_12
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Osteoarthritis, Cartilage, Osteochondral scaffold, Biomaterials, Tissue engineering
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10038996
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