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Factors associated with visual acuity in patients with cystoid macular oedema and Retinitis Pigmentosa.

Liew, G; Moore, AT; Bradley, PD; Webster, AR; Michaelides, M; (2018) Factors associated with visual acuity in patients with cystoid macular oedema and Retinitis Pigmentosa. Ophthalmic Epidemiology , 25 (3) pp. 183-186. 10.1080/09286586.2017.1383448. Green open access

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Abstract

PURPOSE: Retinitis pigmentosa is the most common inherited retinal dystrophy. The factors associated with visual acuity in patients with other retinal diseases are well known, but are poorly understood in patients with retinitis pigmentosa. This knowledge is useful for prognosis and to support secondary endpoints in clinical trials. METHODS: We conducted a cross-sectional study of consecutive patients recruited from the inherited retinal disease service from January 2012 to December 2012. Central macular thickness (CMT) was measured using spectral domain optical coherence tomography. RESULTS: Data were available for 81 patients and 162 eyes. After multivariable analyses, older age, earlier age of onset of symptoms, and thicker CMT were associated with lower visual acuity. Gender and inheritance pattern were not associated with visual acuity. Each decade older age, younger age of onset, and thicker CMT was associated with 0.12, 0.10, and 0.11 worse logarithm of the minimal angle of resolution units of visual acuity, respectively (p < 0.05 for all). CONCLUSIONS: Age, age of onset, and CMT are associated with visual acuity and important factors to measure in studies of retinitis pigmentosa.

Type: Article
Title: Factors associated with visual acuity in patients with cystoid macular oedema and Retinitis Pigmentosa.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/09286586.2017.1383448
Publisher version: https://doi.org/10.1080/09286586.2017.1383448
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Retinitis Pigmentosa, cystoid macular edema, rod cone dystrophy, visual acuity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10038939
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