Kivimäki, M;
Luukkonen, R;
Batty, GD;
Ferrie, JE;
Pentti, J;
Nyberg, ST;
Shipley, MJ;
... Jokela, M; + view all
(2018)
Body mass index and risk of dementia: Analysis of individual-level data from 1.3 million individuals.
Alzheimer's & Dementia
, 14
(5)
pp. 601-609.
10.1016/j.jalz.2017.09.016.
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Abstract
INTRODUCTION: Higher midlife body mass index (BMI) is suggested to increase the risk of dementia, but weight loss during the preclinical dementia phase may mask such effects. METHODS: We examined this hypothesis in 1,349,857 dementia-free participants from 39 cohort studies. BMI was assessed at baseline. Dementia was ascertained at follow-up using linkage to electronic health records (N = 6894). We assumed BMI is little affected by preclinical dementia when assessed decades before dementia onset and much affected when assessed nearer diagnosis. RESULTS: Hazard ratios per 5-kg/m(2) increase in BMI for dementia were 0.71 (95% confidence interval = 0.66-0.77), 0.94 (0.89-0.99), and 1.16 (1.05-1.27) when BMI was assessed 10 years, 10-20 years, and >20 years before dementia diagnosis. CONCLUSIONS: The association between BMI and dementia is likely to be attributable to two different processes: a harmful effect of higher BMI, which is observable in long follow-up, and a reverse-causation effect that makes a higher BMI to appear protective when the follow-up is short.
Type: | Article |
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Title: | Body mass index and risk of dementia: Analysis of individual-level data from 1.3 million individuals |
Location: | United States |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1016/j.jalz.2017.09.016 |
Publisher version: | https://doi.org/10.1016/j.jalz.2017.09.016 |
Language: | English |
Additional information: | ©2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | Bias, Body mass index, Cohort study, Dementia |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
URI: | https://discovery.ucl.ac.uk/id/eprint/10038889 |
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