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Endothelial dysfunction in children with steroid-resistant nephrotic syndrome

Kari, JA; Quinlan, C; Deanfield, J; Shroff, R; Tullus, K; (2017) Endothelial dysfunction in children with steroid-resistant nephrotic syndrome. Iranian Journal of Pediatrics , 27 (4) , Article e8026. 10.5812/ijp.8026. Green open access

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Abstract

Background: Steroid-resistant nephrotic syndrome (SRNS) is associated with early atherosclerosis because of comorbidities including persistent hyperlipidemia and hypertension. The aim of this study was to determine the incidence of abnormal carotid intima-media thickening (cIMT) as an early sign of atherosclerosis in a small group of children with SRNS. Methods: A total of 8 children with SRNS (mean age, 10.8±4.2 years at recruitment andmeandisease duration, 40.9±20.7 months) were studied; all children were normotensive. B-mode ultrasound was used to measure cIMT, and the results were compared with healthy controls. Results: Children with SRNS had significantly thicker CIMT (0.44±0.04 mm), compared to the controls (0.37±0.59mm)(P < 0.01). A high level of total cholesterol (5.4±2.0 mmol/L; normal < 5.2 mmol/L) was reported in these children, while normal levels of lowdensity lipoprotein, very-low-density lipoprotein, triglyceride, and high-density lipoprotein were found. Also, the mean creatinine level was 45.1±15.0 µmol/L, and the mean urea level was 4.2±1.8 mmol/L. Conclusions: Children with SRNS had an abnormal vascular phenotype with a thicker CIMT, compared to the controls and showed evidence of hypercholesterolemia.

Type: Article
Title: Endothelial dysfunction in children with steroid-resistant nephrotic syndrome
Open access status: An open access version is available from UCL Discovery
DOI: 10.5812/ijp.8026
Publisher version: https://doi.org/10.5812/ijp.8026
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Keywords: Steroid-Resistant Nephrotic Syndrome; SRNS; cIMT; Children
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
URI: https://discovery.ucl.ac.uk/id/eprint/10038851
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