Helle, SCJ;
Feng, Q;
Aebersold, MJ;
Hirt, L;
Gruter, RR;
Vahid, A;
Sirianni, A;
... Kornmann, B; + view all
(2017)
Mechanical force induces mitochondrial fission.
eLIFE
, 6
, Article e30292. 10.7554/eLife.30292.
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Abstract
Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive networks constantly remodeled by fission and fusion. Here, we show that mitochondrial fission is triggered by mechanical forces. Mechano-stimulation of mitochondria – via encounter with motile intracellular pathogens, via external pressure applied by an atomic force microscope, or via cell migration across uneven microsurfaces – results in the recruitment of the mitochondrial fission machinery, and subsequent division. We propose that MFF, owing to affinity for narrow mitochondria, acts as a membrane-bound force sensor to recruit the fission machinery to mechanically strained sites. Thus, mitochondria adapt to the environment by sensing and responding to biomechanical cues. Our findings that mechanical triggers can be coupled to biochemical responses in membrane dynamics may explain how organelles orderly cohabit in the crowded cytoplasm.
| Type: | Article |
|---|---|
| Title: | Mechanical force induces mitochondrial fission |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7554/eLife.30292 |
| Publisher version: | https://doi.org/10.7554/eLife.30292 |
| Language: | English |
| Additional information: | © Helle et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, Dynamin-Related Protein-1, Membrane Curvature, Mammalian-Cells, Actin, Resolution, Migration, Constriction, Microscope, Machinery, Bacteria |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10038709 |
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