Atkinson, BN;
Woodward, HL;
Sipthorp, J;
Fish, PV;
(2017)
Regioselective and enantiospecific synthesis of the HSP co-inducer arimoclomol from chiral glycidyl derivatives.
Organic & Biomolecular Chemistry
, 15
(46)
pp. 9794-9799.
10.1039/c7ob02578e.
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Abstract
A new efficient chiral synthesis of enantiopure arimoclomol (2) is reported from (R)-(-)-glycidyl nosylate (11) with complete retention of chiral integrity. Off-target pharmacology of arimoclomol (2) was evaluated against a representative set of drug targets and showed modest binding to a few kinases. Pharmacokinetic data was generated in vivo in mouse and showed a low brain : plasma ratio. These studies will be helpful towards a better understanding of the PK-PD relationship of 2 in disease models.
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